Friday, April 5, 2013

What is the difference between genetic and physical map on the genom?

Just as there are different types of maps of the earth,
geneticists use different maps to express different genetic
information.


A physical map of the genome is like a road
map.  It shows the distance of a specific base pair from a reference point known as an
STS, or Sequence Tagged Site. This is accomplished by cutting up the genome and then
figuring out how the fragments fit into existing STS maps. It is a high-tech approach in
which the sequences of bases in the DNA must be
determined.


A genetic-linkage map shows the order of genes
on a chromosome, and is a way to visualize how and where crossing over has occurred in
meiosis. This can be done through classical genetics studies, by looking at how traits
that come from adjacent genes assort from one generation to the next; it does not
require knowing the nucleotide base sequences that make up the
gene.

No comments:

Post a Comment

What is the meaning of the 4th stanza of Eliot's Preludes, especially the lines "I am moved by fancies...Infinitely suffering thing".

A century old this year, T.S. Eliot's Preludes raises the curtain on his great modernist masterpieces, The Love...