With elements of Naturalism, Of Mice and
            Men portrays men in a struggle for survival against the forces of alienation
            and disenfranchisement wrought by the Great Depression. Since it has often been said
            that much can be told about people by their hands, as well as their eyes, it is an
            interesting exploration of character that examines these hands as representative of
            these desperate characters. 
Lennie
            Small
Portrayed in zoomorphic descriptions,
            Lennie best illustrates what Steinbeck himself described as "the inarticulate and
            powerful yearning of all men."  When he and George arrive in the clearing of Chapter 1,
            after flinging himself down and drinking water with his mouth from a green pool,
            Lennie
dabbled
            his big paw in the water and wiggled his
            fingers...
Also, Lennie "held
            his closed hand" to hide the mouse that he has crushed a mouse with his fingers as he
            has petted it in his pocket. In Chapter 3 he has been petting the pups so much that
            George warns him he will kill them.  George says, "...he [Slim] told' you not to pet the
            pups so much."  When George tells Lennie to give him the pups, Lennie holds "his hands
            out pleadingly."
These scenes foreshadow the petting of
            Curley's wife's hair in Chapter 5.  Interestingly, Steinbeck uses the first descriptive
            word for Lennie's hands from Chapter 1 when Lennie is frightened.  In Chapter 3 during
            the confrontation with Curley, Lennie "covered his face with his huge paws," but when
            George puts out his hands and grabs Slim, saying, "Wait a minute" and tells Lennie to
            let Curley "have it," Lennie "took his hands away from his face."  Then, again, in
            Chapter 5, after Lennie accidentally kills Curley's wife, he "pawed up the hay" trying
            to cover her.
George
            Milton
Very little is mentioned about
            George's hands as he is more cerebral than the other men.  When George points to
            Lennie,         "[H]e indicated Lennie with his thumb."  As he plays cards with Slim in
            the bunkhouse, George metaphorically uses his hands as he "lays out his solitaire
            hand."
It is not until the end of Chapter 5 that there is a
            focus upon George's hands which yet are ruled by his mind.  As he brings the gun to
            Lennie's head:
            readability="6">
 [T]he hand shook violently, but his face set and
            his hand steadied.
Later,
            when the other men arrive at the scene, George "looked steadily at his right hand that
            had held the
            gun."
Curley
In
            at least three instances, Curley is referred to as "handy" (Chapters 2 and 3).   In
            Chapter 2, "his hands closed into  fists" when he enters the bunkhouse; he is mocked for
            having his other hand in a "'Glove fulla vaseline,' George said disgustedly."  When he
            fights with Lennie, his hand is crushed:  "Looks to me like ever' bone in his han' is
            bust." Ironically, Slim uses the word hand when he bends down to
            talk to Curley,
            readability="5">
"You got your senses in hand enought to
            listen?...I think you got your han' caught in a
            machine."
Carlson
Almost
            no mention of Carlson's hands are made.  He cleans his Luger, but the word
            hand(s) is not used.  Instead, he points to Candy's dog with his feet, and
            his "footsteps are heard."  One mention of hands regarding Carlson is figurative as
            he warns Curley about his wife, "You gonna have something on your
            hands."
Perhaps, you may wish to examine other characters
            and how their hands are described.  One such character is Slim, whose hands are "large
            and lean" and "delicate."  When there is conflict, Slim "subdues one hand over the
            other." (Chapter 3)