Describe the connection in the opening words in chapter 5 of Frankenstein.

Did you read the introduction that Mary wrote to explain
how she came up with the story in the first place?  She and some friends were in
Switzerland.  They were entertaining themselves in the midst of poor weather, and
challenged one another to write a ghost story.  Lord Byron, Percy Shelley, and others
were there and conversing about Dr. Darwin's "survival of the fittest" theories among
other scientific ideas of the time.  That night, Mary had a dream that would begin the
story which would be the only one to survive the ghost story challenge.  Keep in mind,
that the Romantics were very closely connected to nature, and that Mary uses weather and
nature/natural surroundings to depict the inner conflict and moods of her characters. 
So, the fact that it was a "dreary night of November" indicates that the end result--the
creature--was not a positive thing.  November is a cold, winter month where people are
often subject to bouts of depression.  The choice of the word "dreary" further supports
the fearful mood of the chapter.  Not to mention, Victor has neglected his health and
his family--two things that are important to his happiness--while embroiled in his
scientific pursuits.