Did the Indus Valley, Mesopatamian, and Eyptain civilizations prefer trade or isolation? What did they trade and with whom?

All three civilizations preferred trade to isolation;
although isolation did provide some protection from invasion. The cataracts on the Nile
River and surrounding desert provided considerable protection for Egypt, and the Indus
Valley was largely protected by the Hindu Kush. Mesopotamia, not so protected, saw the
rise and fall of a number of empires.

In Egypt, the Nile
itself lent itself to trade; in fact the city of Aswan derives its name from an Ancient
Egyptian word meaning "trade." Lenin cloth from Egypt was traded for Ivory and also
cedar from Lebanon for construction.

There is evidence of
Mesopotamian influence in ancient India, particularly the existence of a deity
represented by a bull, most likely borrowed from the Babylonian god Baal. The Dravidians
traded pottery, ivory and pearls for wood, leather, and even olive oil. They also traded
with Persia for gold and precious gems.

The Phoenicians of
Mesopotamia were the foremost traders of the age; in fact their entire empire was based
on trade. They were accomplished sailors and lent a great deal of their culture to other
areas through trade, including their "phonetic"
Alphabet.

More extensive ancient trade is described in the
link below.